Proving Medicines

Organon Aphorism §113

The only exceptions to this are the narcotic medicines. As they, in their primary action, take away sometimes the sensibility and sensation, sometimes the irritability, it frequently happens that in their secondary action, even from moderate experimental doses on healthy bodies, an increased sensibility (and a greater irritability) is observable.

Samuel Hahnemann, Organon of Medicine, 6th edition (Boericke translation, public domain).

Expert explanation & clinical interpretation for this aphorism are coming soon.