Preparation of Medicines

Organon Aphorism §272

Such a globule,1 placed dry upon the tongue, is one of the smallest doses for a moderate recent case of illness. Here but few nerves are touched by the medicine. A similar globule, crushed with some sugar of milk and dissolved in a good deal of water (§ 247) and stirred well before every administration will produce a far more powerful medicine for the use of several days. Every dose, no matter how minute, touches, on the contrary, many nerves.

Samuel Hahnemann, Organon of Medicine, 6th edition (Boericke translation, public domain).

Expert explanation & clinical interpretation for this aphorism are coming soon.