Preparation of Medicines

Organon Aphorism §282

It would be a certain sign that the doses were altogether too large, if during treatment, especially in chronic disease, the first dose should bring forth a so-called homoeopathic aggravation, that is, a marked increase of the original morbid symptoms first discovered and in the same way every repeated dose (§ 247) however modified somewhat by shaking before its administration (i.e., more highly dynamized).

Samuel Hahnemann, Organon of Medicine, 6th edition (Boericke translation, public domain).

Expert explanation & clinical interpretation for this aphorism are coming soon.